Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Struct Biol. 1998 Dec;5(12):1033-6.

HIV-1 A-rich RNA loop mimics the tRNA anticodon structure.

Author information

1
Department of Structural Biology, Stanford University School of Medicine, California 94305-5400, USA.

Abstract

Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription.

PMID:
9846871
DOI:
10.1038/4141
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center