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Immunity. 1998 Nov;9(5):721-31.

A critical role for complement in maintenance of self-tolerance.

Author information

1
The Center for Blood Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

The role of complement in the maintenance of self-tolerance has been examined in two models: an immunoglobulin transgenic model of peripheral tolerance and a lupus-like murine model of CD95 (Fas) deficiency. We find that self-reactive B lymphocytes deficient in complement receptors CD21/CD35 or transferred into mice deficient in the complement protein C4 are not anergized by soluble self-antigen. In the second model, deficiency in CD21/CD35 or C4 combined with CD95 deficiency results in high titers of anti-nuclear antibodies leading to severe lupus-like disease. These findings suggest a novel role for the complement system in B cell tolerance and provide insight into the genetic association of complement deficiency with susceptibility to systemic lupus erythematosus.

PMID:
9846493
DOI:
10.1016/s1074-7613(00)80669-x
[Indexed for MEDLINE]
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