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Am J Psychiatry. 1998 Dec;155(12):1784-6.

Partial volume decrease of the thalamus in relatives of patients with schizophrenia.

Author information

1
Department of Psychiatry, University Hospital Utrecht, The Netherlands.

Abstract

OBJECTIVE:

The authors' goal was to compare the thalamic, total brain, and intracranial volumes of patients with schizophrenia, their healthy siblings, and normal comparison subjects.

METHOD:

Magnetic resonance imaging (MRI) brain scans were obtained for 32 same-sex siblings who were discordant for schizophrenia and 32 matched normal comparison subjects.

RESULTS:

Mean total thalamic volume, corrected for total brain volume, was significantly different among affected siblings, unaffected siblings, and comparison subjects. Thalamic volume was smallest in the patients; thalamic volume in their siblings was smaller than that of comparison subjects but larger than that of the patients with schizophrenia.

CONCLUSIONS:

These results suggest that healthy siblings of patients with schizophrenia partially share the thalamic abnormalities of their affected relatives.

PMID:
9842796
DOI:
10.1176/ajp.155.12.1784
[Indexed for MEDLINE]

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