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Cancer Lett. 1998 Sep 11;131(1):113-5.

Hyaluronidase as additive to induction chemotherapy in advanced squamous cell carcinoma of the head and neck.

Author information

1
1st Medical Department, Institute of Oncology, Klagenfurt General Hospital, Austria.

Abstract

Forty-eight patients with advanced head and neck tumours were treated with irradiation and concomitant chemotherapy with cisplatin, vindesine and hyaluronidase. The disease-free survival rate at 5 years was 47%. The toxic effects were mucositis (48 patients), nausea (25 patients, vomiting in six patients), bone marrow depression (15 patients) and peripheral neuropathy (14 patients). The results warrant a randomized trial.

PMID:
9839626
DOI:
10.1016/s0304-3835(98)00207-9
[Indexed for MEDLINE]

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