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Brain Res Mol Brain Res. 1998 Dec 10;63(1):180-3.

Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice.

Author information

1
Department of Medical Biochemistry, Göteborg University, Box 440 SE 405 30, Göteborg, Sweden. samuel.gebre-medlem.gu.se

Abstract

Islet amyloid polypeptide (IAPP or amylin) is predominantly expressed by insulin cells, but occurs also in primary sensory neurons in the rat. Here, using mice targeted for a null mutation in the IAPP gene, we establish murine expression of IAPP in sensory neurons; its distribution in a population of calcitonin gene-related peptide-containing neurons in the spinal cord and dorsal root ganglion is similar to that previously described in the rat. We also report the IAPP mutant mice display a reduced pain response in the paw formalin test. Adjuvant-induced joint inflammation was not altered in IAPP mutants, arguing against a peripheral inflammatory abnormality. These findings lead us to suggest that IAPP has a pro-nociceptive function in primary sensory neurons.

PMID:
9838101
DOI:
10.1016/s0169-328x(98)00269-1
[Indexed for MEDLINE]

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