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Semin Cell Dev Biol. 1998 Oct;9(5):503-9.

Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells.

Author information

1
Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, Helsinki, 00300, Finland.

Abstract

The targeting of proteins and lipids to the cell surface domains of polarized cells is not a simple bulk flow process but requires sorting into distinct apical and basolateral pathways from the trans-Golgi network. Here, we describe the sorting determinants in the cargo molecules, the cellular sorting machineries responsible for the hierarchical read-out of the signals, and the mechanisms of cargo delivery. Furthermore, we discuss the implications of these findings for protein-lipid interactions in other cellular machineries.

PMID:
9835637
DOI:
10.1006/scdb.1998.0258
[Indexed for MEDLINE]

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