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J Cardiovasc Electrophysiol. 1998 Nov;9(11):1167-72.

ST segment elevation induced by class IC antiarrhythmic agents: underlying electrophysiologic mechanisms and insights into drug-induced proarrhythmia.

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Harvard-Thorndike Electrophysiology Institute, Beth Israel Deaconess Hospital, Boston, Massachusetts 02215, USA.


Three patients in whom Class IC sodium channel blockers induced ST segment elevation in leads V1 through V3 are described. The underlying electrophysiologic mechanism, implications for drug-induced proarrhythmia, and the relationship of the finding to the Brugada syndrome type of idiopathic ventricular fibrillation are discussed.

[Indexed for MEDLINE]

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