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Chem Biol. 1998 Nov;5(11):R277-83.

Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme.

Author information

1
Department of Chemistry and Biochemistry University of California San Diego La Jolla CA 92093-0358 USA. ytor@ucsd.edu.

Abstract

Aminoglycoside antibiotics inhibit protein biosynthesis and various ribozymes. Structural electrostatic complementarity can explain the inhibition mechanism of the hammerhead ribozyme: positively charged ammonium groups match the negatively charged metal-ion-binding pockets created by the RNA fold's electrostatic field.

PMID:
9831530
DOI:
10.1016/s1074-5521(98)90286-1
[Indexed for MEDLINE]
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