Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuroreport. 1998 Oct 5;9(14):3259-63.

Expression of copper trafficking genes in the mouse brain.

Author information

1
Department of Molecular Genetic Research, National Institute for Longevity Sciences, Oobu, Aichi, Japan.

Abstract

Copper homeostasis in the brain must be strictly maintained, since copper is an essential trace element and is potentially toxic. To understand the mechanism of copper homeostasis in the brain, we cloned several mouse homologues of copper trafficking genes and performed in situ hybridization histochemistry. mCTR1, mATX1, and mATP7a were highly expressed in the choroid plexus, indicating that the choroid plexus uses the trafficking pathway from uptake to efflux to transport copper to the cerebrospinal fluids. We suggest that these genes may regulate copper concentration in the brain through the choroid plexus.

PMID:
9831461
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Support Center