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Eur J Pharmacol. 1998 Oct 16;359(1):1-18.

Endocannabinoids.

Author information

1
Hebrew University, Medical Faculty, Jerusalem, Israel. mechou@yam-suff.cc.huji.ac.il

Abstract

The background knowledge leading to the isolation and identification of anandamide and 2-arachidonoyl glycerol, the principal endocannabinoids is described. The structure-activity relationships of these lipid derivatives are summarized. Selected biochemical and pharmacological topics in this field are discussed, the main ones being levels of endocannabinoids in unstimulated tissue and cells, biosynthesis, release and inactivation of endocannabinoids, the effects of 'entourage' compounds on the activities of anandamide and 2-arachidonoyl glycerol, their signaling mechanisms and effects in animals.

PMID:
9831287
DOI:
10.1016/s0014-2999(98)00649-9
[Indexed for MEDLINE]

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