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J Pediatr Endocrinol Metab. 1998 Nov-Dec;11(6):751-6.

Diagnostic value of serological markers for celiac disease in diabetic children and adolescents.

Author information

1
Department of Pediatrics, Ramón y Cajal Hospital, Alcalá de Henares University School of Medicine, Madrid, Spain.

Abstract

OBJECTIVE:

To determine the accuracy of antigliadin and antiendomysium antibodies for the diagnosis of celiac disease in diabetic children and adolescents with and without digestive symptoms.

STUDY DESIGN:

177 children and adolescents with IDDM aged 15.4 +/- 5.4 years (mean +/- SD). Antigliadin (ELISA) and antiendomysium (IFI) antibodies were measured in 177 and 35 patients, respectively.

RESULTS:

Seven of 177 patients (3.9%; 95% confidence interval: 1.1-6.7) had celiac disease. The specificities of antiendomysium antibodies test (83%), IgA-antigliadin antibodies test (80%) and IgG-antigliadin antibodies test (90%) and the positive predictive values of these antibodies (55-75%) were lower than those obtained with the combined determination of these antibodies (100%). Negative antibodies and normal mucosa in one determination did not rule out the development of celiac disease later.

CONCLUSIONS:

The combined determination of antigliadin and antiendomysium antibodies is the test of choice in screening for celiac disease in diabetic patients. The yearly investigation of these antibodies is a reliable method for detecting silent celiac disease in this population.

PMID:
9829231
DOI:
10.1515/jpem.1998.11.6.751
[Indexed for MEDLINE]

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