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Biosens Bioelectron. 1998 Oct 1;13(7-8):757-62.

DNA biosensors based on peptide nucleic acid (PNA) recognition layers. A review.

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Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces 88003, USA.


Peptide nucleic acid (PNA), originally developed as a gene-targeting drug, has demonstrated remarkable hybridization properties towards complementary oligonucleotides. Biosensors based on replacement of the DNA recognition layer with a PNA one, offer greatly improved distinction between closely related sequences, as well as several other attractive advantages. The present review discusses the unique structural, hybridization, and recognition features of PNA probes, along with the opportunities accrued from the use of PNA recognition layers in DNA diagnostics.

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