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Gut. 1998 Dec;43(6):856-60.

Role of NF-kappaB in immune and inflammatory responses in the gut.

Author information

1
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Langenbeckstrasse, 55101 Mainz, Germany.

Abstract

NF-kappaB is a pleiotropic transcription factor with key functions in the intestinal immune system. NF-kappaB family members control transcriptional activity of various promoters of proinflammatory cytokines, cell surface receptors, transcription factors, and adhesion molecules that are involved in intestinal inflammation. The perpetuated activation of NF-kappaB in patients with active inflammatory bowel disease suggests that regulation of NF-kappaB activity is a very attractive target for therapeutic intervention. Such strategies include antioxidants, proteasome inhibitors, inhibition of NF-kappaB by adenoviral I kappaB alpha expression vectors, and antisense DNA targeting of NF-kappaB. These approaches will hopefully permit the design of new treatment strategies for chronic intestinal inflammation.

PMID:
9824616
PMCID:
PMC1727350
[Indexed for MEDLINE]
Free PMC Article
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