Gastric myoelectrical activity in healthy children and children with functional dyspepsia

Dig Dis Sci. 1998 Nov;43(11):2384-91. doi: 10.1023/a:1026661627304.

Abstract

The aim of this study was to investigate abnormalities in pediatric patients with functional dyspepsia. Fifteen symptomatic pediatric patients diagnosed with functional dyspepsia and 17 aged-matched healthy controls were studied. Gastric myoelectrical activity was recorded using surface electrogastrography for 1 hr in the fasting state and 1 hr after a test meal. It was found that, in comparison with the controls, the children with functional dyspepsia had a lower percentage of 2- to 4-cpm slow waves in both fasting state (66.0+/-4.7% vs 79.7+/-3.1%, P < 0.07) and fed state (72.4+/-5.4% vs 85.0+/-2.9%, P < 0.04), and a significantly higher instability of the dominant frequency in both fasting state (0.50+/-0.05 vs 0.31+/-0.04, P < 0.01) and fed state (0.39+/-0.05 vs 0.25+/-0.03, P < 0.05). It was also found the postprandial increase in EGG dominant power in the patients was inversely correlated with the total symptom score (r = 0.63, P = 0.03). It was concluded that abnormal gastric myoelectrical activity may play a role in the pathogenesis of pediatric functional dyspepsia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Dyspepsia / physiopathology*
  • Electrodes
  • Electrodiagnosis / instrumentation
  • Electrodiagnosis / methods
  • Electrodiagnosis / statistics & numerical data
  • Fasting / physiology
  • Female
  • Humans
  • Male
  • Myoelectric Complex, Migrating / physiology*
  • Postprandial Period
  • Reference Values
  • Signal Processing, Computer-Assisted / instrumentation
  • Statistics, Nonparametric
  • Stomach / physiopathology