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Acta Paediatr Jpn. 1998 Oct;40(5):424-6.

Values for urinary beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase in normal healthy infants.

Author information

1
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan. mnishida@ped.kpu-m.ac.jp

Abstract

BACKGROUND:

Measuring urinary beta 2 microglobin (B2M) and N-acetyl-beta-D-glucosaminidase (NAG) excretion is widely used as a valuable clinical tool in assessing renal tubular lesions. However, few data are available on normal values for urinary excretion of B2M and NAG in infancy.

METHODS:

Urinary B2M and NAG were measured in healthy infants. The logarithmic values of urinary B2M, NAG, B2M/creatinine ratio and NAG/creatinine ratio were distributed almost normally and reference ranges were calculated from the logarithms of the observed values.

RESULTS:

The levels of urinary B2M and B2M/creatinine ratio were highest in the 1-month-old group, followed by a decrease during the first 3 months. Urinary B2M excretions in the 3-month-old group showed rather lower levels than those of the 12-month-old and 36-month-old groups. Although urinary NAG excretions were almost constant throughout all groups, urinary NAG/creatinine ratio decreased gradually until 3 years of age.

CONCLUSIONS:

We suggest that these reference ranges are of importance in evaluating tubular damage due to a variety of renal diseases in infancy.

[Indexed for MEDLINE]

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