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Biol Psychiatry. 1998 Nov 15;44(10):959-72.

Toward a generalizable model of symptoms in major depressive disorder.

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1
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA.

Abstract

BACKGROUND:

This study has two goals: 1) to establish a generalizable model of the symptoms observed in outpatients with major depressive disorder (MDD); and 2) to compare symptom coverage of the Inventory of Depressive Symptomatology, Clinician-Rated (IDS-C) and Self-Report (IDS-SR) to that of the Hamilton Depression Rating Scale (HDRS) and Beck Depression Inventory (BDI).

METHODS:

A factor analysis of IDS-C, IDS-SR, HDRS, and BDI items was carried out on 324 adult outpatients with MDD. Patients with coexisting Axis I or III illness or those taking psychotropic medication were excluded.

RESULTS:

Ten primary factors were identified, six of which were substantially intercorrelated, defining a second-order factor of general depression severity. Schmid-Leiman orthogonalization identified the symptoms most associated with general severity.

CONCLUSIONS:

The IDS provided more complete factors coverage than did the HDRS or BDI and thus may be more useful in research on symptom profiles.

PMID:
9821560
[Indexed for MEDLINE]
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