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Curr Opin Biotechnol. 1998 Oct;9(5):497-501.

Advances in refolding of proteins produced in E. coli.

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Institut für Biotechnologie, Martin Luther Universität Halle-Wittenberg, Halle, Germany.


Inclusion body production is a common theme in recombinant protein technology. Hence, renaturation of these inclusion body proteins is a field of increasing interest for gaining large amounts of proteins. Recent developments of renaturation procedures include the inhibition of aggregation during refolding by the application of low molecular weight additives and matrix-bound renaturation techniques.

[Indexed for MEDLINE]

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