Very high cytochrome P4501A2 activity and nonresponse to clozapine

Arch Gen Psychiatry. 1998 Nov;55(11):1048-50. doi: 10.1001/archpsyc.55.11.1048.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Antipsychotic Agents / pharmacokinetics*
  • Antipsychotic Agents / therapeutic use*
  • Clozapine / pharmacokinetics*
  • Clozapine / therapeutic use*
  • Cytochrome P-450 CYP1A2 / drug effects
  • Cytochrome P-450 CYP1A2 / metabolism*
  • Female
  • Humans
  • Male
  • Psychiatric Status Rating Scales
  • Schizophrenia / blood
  • Schizophrenia / diagnosis
  • Schizophrenia / drug therapy*
  • Smoking / metabolism
  • Treatment Outcome

Substances

  • Antipsychotic Agents
  • Cytochrome P-450 CYP1A2
  • Clozapine