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Mol Gen Genet. 1998 Oct;259(6):610-4.

Effect of IciA protein on the expression of the nrd gene encoding ribonucleoside diphosphate reductase in E. coli.

Author information

1
Institute for Molecular Biology and Genetics, Seoul National University, Korea.

Abstract

The E. coli nrd operon contains the genes encoding the two subunits of ribonucleoside diphosphate reductase. We found that the IciA protein binds specifically to the AT-rich upstream region of nrd promoter. In vivo overexpression of IciA increases the expression of nrd gene by four- to five-fold, suggesting that IciA functions as a transcriptional activator for the nrd gene.

PMID:
9819053
DOI:
10.1007/s004380050854
[Indexed for MEDLINE]

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