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J Antimicrob Chemother. 1998 Oct;42(4):531-3.

Comparison of the in-vitro activity of voriconazole (UK-109,496), itraconazole and amphotericin B against clinical isolates of Aspergillus fumigatus.

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1
Unidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.

Abstract

Voriconazole was compared with amphotericin B and itraconazole by a modification of the NCCLS microdilution reference method for yeasts against 62 clinical isolates of Aspergillus fumigatus. MICs of voriconazole were slightly lower than those of amphotericin B and itraconazole. The MIC of voriconazole at which 90% of isolates were inhibited was 1 mg/L and the MIC range was 0.25-2 mg/L. Voriconazole is a new antifungal agent with potential for use in the treatment of A. fumigatus infections.

PMID:
9818755
DOI:
10.1093/jac/42.4.531
[Indexed for MEDLINE]

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