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Immunol Today. 1998 Nov;19(11):519-23.

Complement diversity: a mechanism for generating immune diversity?

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Dept of Pathology and Laboratory of Medicine, University of Pennsylvania, Philadelphia 19104, USA.


Unlike mammalian species, several cold-blooded species have been shown to possess multiple forms of complement components. The multiple forms of C3 characterized in several fish species can bind with different specificities to various complement-activating surfaces. Here, Oriol Sunyer, Ioannis Zarkadis and John Lambris explore the possible advantages conferred by having multiple forms of individual complement proteins in a single organism.

[Indexed for MEDLINE]

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