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Immunol Today. 1998 Nov;19(11):511-4.

The dynamic structure of the germinal center.

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Deutsches Rheuma ForschungsZentrum, Berlin, Germany.


Analysis of germinal centers (GCs) in chronically inflamed human tonsils has led to the dogma that GCs contain two compartments with separate functions: a dark zone where B cells proliferate and hypermutate; and a light zone where selection and differentiation occur. However, here Stephanie Camacho and colleagues discuss immunohistological analysis of splenic GCs arising de novo that reveal a more plastic structure.

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