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Immunol Today. 1998 Nov;19(11):502-6.

CD40 and epithelial cells: across the great divide.

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CRC Institute for Cancer Studies, University of Birmingham Medical School, UK.


The widespread expression of CD40 in normal epithelial cells and carcinoma cells suggests that this receptor has important, additional influences beyond that of regulating immune responses. Here, Lawrence Young and colleagues discuss the effect of CD40 ligation on epithelial cells and consider the role of this pathway in the pathogenesis and treatment of carcinomas.

[Indexed for MEDLINE]

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