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Curr Opin Cell Biol. 1998 Oct;10(5):660-6.

Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors.

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Department of Stomatology, University of California San Francisco 94143-0512, USA.


During early development, a subset of fetal (placental) cytotrophoblasts exhibits tumor-like behavior and invades the uterus. To access a supply of maternal blood, they invade arterioles and form heterotypic interactions with, and replace, resident maternal endothelium, creating a hybrid uterine vasculature. Recently, it has become clear that invading cytotrophoblasts transform their adhesion receptor phenotype to resemble the endothelial cells they replace. Furthermore, they express vasculogenic factors and receptors. Is this a form of vasculogenesis?

[Indexed for MEDLINE]

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