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Curr Opin Cell Biol. 1998 Oct;10(5):654-9.

ADAMs: focus on the protease domain.

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  • 1Immunex Corporation, Seattle, WA 98101, USA.

Abstract

ADAMs are proteins containing a disintegrin and metalloproteinase domain. Several important insights were provided in the past year regarding ADAM metalloproteinases. ADAM 10 was implicated in the Notch signaling pathway. ADAM 17 was shown to be the long sought after tumor necrosis factor-alpha convertase and the crystal structure of its metalloproteinase domain was determined.

PMID:
9818177
[PubMed - indexed for MEDLINE]
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