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Curr Opin Cell Biol. 1998 Oct;10(5):640-6.

Extracellular matrix signaling: integration of form and function in normal and malignant cells.

Author information

1
Surgical Research Laboratory, University of California, San Francisco 94143, USA.

Abstract

A growing number of studies have established reciprocal linkages between extracellular matrix (ECM)-integrins, growth factor signaling and cell-cell adhesion molecules. ECM-dependent tissue-specific gene expression has also been linked to chromatin remodeling. With respect to tissue morphogenesis and differentiation, crosstalk has been established between the ECM and the homeobox morphoregulatory genes. Each of these linkages is profoundly influenced by the cell's microenvironment and the resulting tissue form. Thus for a cell to achieve a differentiated phenotype, the ECM molecules and their receptors must integrate both form and function. In contrast, mutated genes and aberrant interactions with the microenvironment conspire to undermine this integration, often resulting in malignant transformation.

PMID:
9818175
PMCID:
PMC2933204
DOI:
10.1016/s0955-0674(98)80040-9
[Indexed for MEDLINE]
Free PMC Article

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