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Curr Opin Cell Biol. 1998 Oct;10(5):602-8.

Matrix metalloproteinase degradation of extracellular matrix: biological consequences.

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Department of Pediatrics, Washington University School of Medicine, Barnes-Jewish Hospital, St Louis, MO 63110, USA.


Targeted mutagenesis has allowed investigators to perform controlled experiments in mammals and determine the contribution of individual proteins to physiologic and pathologic processes. Recent lessons learned from matrix metalloproteinase gene targeted mice and other in vivo observations have given new life to old concepts regarding the role of proteolytic fragments of extracellular matrix proteins in regulating a variety of critical processes in cell biology.

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