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J Neuropsychiatry Clin Neurosci. 1998 Fall;10(4):448-52.

A longitudinal study of psychosis due to a general medical (neurological) condition: establishing predictive and construct validity.

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Wellesley Hospital, Toronto, Ontario, Canada.


A sample of 44 patients with a neurological disorder and a DSM-IV diagnosis of Psychosis due to a General Medical Condition were followed on average for 4 years and their response to treatment and clinical course noted. Outcome was more benign than in schizophrenia, with most patients having a brief duration of psychosis and good response to small doses of neuroleptics. One-fourth of patients suffered a single, brief psychotic episode with return to full premorbid function. None required maintenance neuroleptic treatment. The outcome and descriptive profile of the disorder also differed from late-onset schizophrenia. Thus, Psychosis due to a General Medical (Neurological) Condition does appear to have predictive validity. However, no temporal association was found between the neurological illness and psychosis. Possible reasons for this are discussed.

[Indexed for MEDLINE]

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