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Biochim Biophys Acta. 1998 Nov 19;1408(2-3):173-9.

Synthesis, processing and secretion of surfactant proteins B and C.

Author information

1
Children's Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. tim.weaver@chmcc.org

Abstract

Two small, hydrophobic peptides, surfactant protein (SP)-B and SP-C, play important roles in the generation and maintenance of a surface active film in the alveolus. Isolation and characterization of the cDNAs encoding SP-B and SP-C indicate that both peptides are synthesized as larger proproteins which are proteolytically processed to peptides with Mr approx. 8000 and 4000, respectively. The biosynthetic pathway leading to generation and secretion of the biophysically active mature SP-B and SP-C peptides is reviewed.

PMID:
9813310
DOI:
10.1016/s0925-4439(98)00066-0
[Indexed for MEDLINE]
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