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Brain Res. 1998 Nov 23;812(1-2):113-20.

Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat.

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1
Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela.

Abstract

The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the basolateral amygdala were measured by in vivo microdialysis. Inescapable, but not escapable, shock increased extracellular 5-HT in the amygdala relative to restrained controls. Basal levels of 5-HT were elevated 24 h after inescapable shock, and previously inescapably shocked subjects exhibited an exaggerated 5-HT response to two brief footshocks. Levels of extracellular 5-HIAA did not follow any particular pattern and were not correlated with the changes in 5-HT.

PMID:
9813270
[Indexed for MEDLINE]
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