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Zhongguo Yao Li Xue Bao. 1996 May;17(3):261-3.

Inhibitory effect of quercetin on tumor necrosis factor and interleukin-1 beta pro-osteoclastic activities.

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1
Research Laboratory of Natural and Synthetic Drugs, School of Pharmacy, Second Military Medical University, Shanghai, China.

Abstract

AIM:

To study the effects of quercetin on tumor necrosis factor (TNF) and interleukin-1 beta (IL-1 beta) pro-osteoclastic activities.

METHODS:

[3H] TdR uptake by osteoblasts was used to measure cell proliferation, microspectrophotometer for cellular AIP activity using p-nitrophenyl phosphate as enzyme substrate, and radioimmunoassay for prostaglandin E2.

RESULTS:

Quercetin 5-40 mumol.L-1 reduced the inhibition of cell proliferation and AIP activity induced by TNF or IL-1 beta in a concentration-dependent manner. PGE2 production stimulated by either cytokines was also reduced by quercetin at 20 and 40 mumol.L-1.

CONCLUSION:

quercetin exerted a marked inhibitory effect on TNF and IL-1 activities, related to their pro-osteoclastic function.

PMID:
9812753
[Indexed for MEDLINE]
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