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J Virol. 1998 Dec;72(12):10265-9.

Alphavirus replicase protein NSP1 induces filopodia and rearrangement of actin filaments.

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1
Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, Finland.

Abstract

Expression of the NSP1 protein of Semliki Forest virus and Sindbis virus in cultured cells induced filopodia-like extensions containing NSP1 but not F actin. The actin stress fibers disappeared, whereas vimentin, keratin, and tubulin networks remained intact. The effects of NSP1 were dependent on its palmitoylation but not on its enzymatic activities and were also observed in virus-infected cells.

PMID:
9811773
PMCID:
PMC110611
[Indexed for MEDLINE]
Free PMC Article
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