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Curr Opin Neurobiol. 1998 Oct;8(5):613-8.

Linking extracellular survival signals and the apoptotic machinery.

Author information

1
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor 48109, USA. Gabriel.Nunez@umich.edu

Abstract

The survival of cells in multicellular organisms requires continuous stimulation from the extracellular environment. The phosphatidylinositol-3' kinase/Akt signaling cascade has been identified as a critical pathway for the transduction of extracellular survival signals. The finding that the pro-apoptotic protein BAD is a substrate of Akt/PKB has provided the first link between extracellular survival signals and the apoptotic machinery.

PMID:
9811624
[Indexed for MEDLINE]

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