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Nat Med. 1998 Nov;4(11):1334-6.

Imaging proliferation in vivo with [F-18]FLT and positron emission tomography.

Author information

1
Karmanos Cancer Institute, Department of Medicine, Wayne State University, Detroit Medical Center, MI 48301, USA. shieldsA@karmanos.org

Abstract

Positron emission tomography (PET) is now regularly used in the diagnosis and staging of cancer. These uses and its ability to monitor treatment response would be aided by the development of imaging agents that can be used to measure tissue and tumor proliferation. We have developed and tested [F-18]FLT (3'-deoxy-3'-fluorothymidine); it is resistant to degradation, is retained in proliferating tissues by the action of thymidine kinase 1 (TK), and produces high-contrast images of normal marrow and tumors in canine and human subjects.

PMID:
9809561
DOI:
10.1038/3337
[Indexed for MEDLINE]

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