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FEMS Microbiol Lett. 1998 Oct 15;167(2):107-11.

An Escherichia coli gene responsive to heavy metals.

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Department of Molecular Microbiology and Biotechnology, Tel-Aviv University, Israel.


Using in vivo translational gene fusion in Escherichia coli K-12 we identified a gene that is specifically induced by heavy metals, cadmium, mercury and zinc, at nmolar concentrations. This gene was identified by homology to known zinc and cadmium transporters. We created a disruption of the gene that resulted only in a minor increase in sensitivity to cadmium, suggesting that the fusion, which is at the carboxy-terminal end of the molecule, probably allows for at least partial activity of the protein.

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