Format

Send to

Choose Destination
Neurosci Biobehav Rev. 1998 Oct;22(6):679-84.

Viruses as transneuronal tracers for defining neural circuits.

Author information

1
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Live viruses can be used as tools to label chains of neurons and thus to define functionally connected CNS circuits. This review summarizes the background and general principles involved in using the viral tracing technology. An attenuated form of a pig herpes virus, known as the Bartha's K strain of pseudorabies virus, has proven to be a useful type of virus for the analysis of CNS systems in the rat. The properties of this virus and the evidence for its specificity in causing trans-synaptic infections is discussed.

PMID:
9809303
DOI:
10.1016/s0149-7634(98)00006-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center