Format

Send to

Choose Destination
Clin Chem Lab Med. 1998 Aug;36(8):535-9.

Signal transduction pathways and modulation of gene activity.

Author information

1
Unité des Virus Oncogènes, URA 1644 du CNRS, Institut Pasteur, Paris, France.

Abstract

Research over the last decade has provided us with much information about the mechanisms that integrate signal transduction pathways with specific gene expression programs. We discuss the types of mechanisms used by different pathways to modulate transcription factor activity, citing examples from diverse molecular systems. Careful regulation of these pathways is essential to maintain balanced transcriptional control. Understanding the mechanisms that control gene activity will enable us to intervene therapeutically in diseases associated with deregulated transcriptional activity.

PMID:
9806455
DOI:
10.1515/CCLM.1998.091
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Sheridan PubFactory
Loading ...
Support Center