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Semin Arthritis Rheum. 1998 Oct;28(2):80-7.

Predictors of lymphoma development in primary Sjögren's syndrome.

Author information

1
Centre for Rheumatology/Bloomsbury Rheumatology Unit, Department of Medicine, University College London.

Abstract

OBJECTIVE:

To determine the clinical and laboratory predictors of lymphoma development in primary Sjögren's syndrome (pSS).

METHODS:

Seventy-two patients with pSS were studied. Demographic data, clinical features, serum gamma-globulin levels, autoantibodies, and HLA status were reviewed. For statistical analysis, Mann-Whitney U-test, Fisher's exact test, logistic regression analysis, Kaplan-Meier method, and log-rank tests were applied.

RESULTS:

Five patients developed a distinct non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue (MALT). A history of swollen salivary glands, lymphadenopathy, and leg ulcers predicted lymphoma development.

CONCLUSION:

Patients with pSS are at increased risk of lymphoma development, and those who have the above risk factors must be carefully observed.

PMID:
9806368
DOI:
10.1016/s0049-0172(98)80040-1
[Indexed for MEDLINE]

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