Send to

Choose Destination
Int J Clin Lab Res. 1998;28(3):141-7.

Signalling by proteolysis: death receptors induce apoptosis.

Author information

Department of Immunology and Cell Biology, Mario Negri Institute, Milan, Italy.


Apoptosis, or programmed cell death, is a genetically regulated mechanism with a central role in both metazoan development and homeostasis. Death receptors (Fas, TNFR-2, DR3, and TRAIL receptors) induce apoptosis upon ligation to cognate ligands or ectopic expression. The assembly of a death-inducing signalling complex occurs in a hierarchical manner upon receptor activation. The death domain of the receptor binds to the corresponding domain of the adapter molecule FADD, which in turn recruits the zymogen form of the death protease FLICE (MACH/caspase-8). Upon approximation, FLICE "zymogens" attain a sufficient concentration to self-activate and to trigger the apoptotic pathway. For the first time, a transmembrane receptor directly engaging a protease at the signalling complex and subsequently triggering a proteolytic signalling cascade is described.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center