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Vaccine. 1998 Nov;16(19):1818-21.

DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans.

Author information

1
University of South Florida College of Medicine, Department of Medical Microbiology and Immunology, Tampa 33612, USA. kugen@com1.med.usf.edu

Abstract

Humoral and cellular immune responses have been produced by intramuscular vaccination with DNA plasmids expressing HIV-1 genes, suggesting possible immunotherapeutic and prophylactic value for these constructs. Vaccination with these constructs has decreased HIV-1 viral load in HIV-1-infected chimpanzees. In addition, naive (i.e. non-HIV-1-infected) chimpanzees were protected against a heterologous challenge with HIV-1. Ongoing phase I clinical trials show that therapeutic vaccinations indeed boost anti-HIV-1 immune responses in humans. A therapeutic phase I trial on humans with these constructs induced a good safety profile and also demonstrated an immunological potentiation. These findings indicate that further studies with these constructs in humans are warranted.

PMID:
9795386
DOI:
10.1016/s0264-410x(98)00180-7
[Indexed for MEDLINE]

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