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Curr Opin Immunol. 1998 Oct;10(5):581-7.

How do cytotoxic lymphocytes kill their targets?

Author information

1
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110-1093, USA.

Abstract

CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrates.

PMID:
9794837
DOI:
10.1016/s0952-7915(98)80227-6
[Indexed for MEDLINE]

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