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Curr Opin Immunol. 1998 Oct;10(5):559-63.

TRAIL: a molecule with multiple receptors and control mechanisms.

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  • 1Department of Immunobiology, Immunex Corporation, 51 University Street,Seattle, WA 98101-2936, USA.


Apoptosis research is benefiting from bioinformatic approaches to identify new components of the cell death machinery and novel cell death inducers/receptors. Over the past year, knowledge of the system involving TNF-related apoptosis-inducing ligand (TRAIL) and its receptors has increased via genomic database analysis to include four distinct receptors that interact with a single ligand. Currently, these molecules are of major interest due to their potential roles and application in cancer therapy.

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