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Curr Opin Immunol. 1998 Oct;10(5):545-51.

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis.

Author information

1
Tumor Immunology Program, German Cancer Research Center, Im NeuenheimerFeld 280, D-69120, Heidelberg, Germany. m.peter@dkfz-heidelberg.de

Abstract

This review covers recent advances of CD95 signaling. It focuses on CD95-interacting molecules, formation of the death inducing signaling complex and the role of caspases, particularly caspase-8, and their death substrates. We also discuss the relevance of mitochondria in the CD95-mediated apoptotic process and how viral proteins interfere with crucial steps of this signaling pathway.

PMID:
9794832
DOI:
10.1016/s0952-7915(98)80222-7
[Indexed for MEDLINE]

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