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Curr Opin Immunol. 1998 Oct;10(5):564-72.

Tumor expression of Fas ligand (CD95L) and the consequences.

Author information

1
Laboratory of Tumour Immunology, Division of Oncology, University Hospital Geneva, 24 rue Micheli-du-Crest, CH-1211, Geneva 14, Switzerland. Paul.Walker@hcuge.ch

Abstract

Tumors of diverse origin have recently been shown to express CD95 ligand and to induce apoptosis in CD95-expressing targets in vitro; however, in vivo, enhanced tumor growth and rejection have both been observed as a consequence of either immunosuppressive or proinflammatory functions of CD95 ligand. The final in vivo outcome of CD95 ligand expression will depend upon a complex balance of interactions relevant for each tumor in its particular microenvironment.

PMID:
9794830
DOI:
10.1016/s0952-7915(98)80225-2
[Indexed for MEDLINE]

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