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Curr Opin Genet Dev. 1998 Oct;8(5):545-51.

A transcription factor party during blood cell differentiation.

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European Molecular Biology Laboratory, Meyerhofstr. 1, 69117, Heidelberg, Germany.


Recent studies have shown that hematopoietic transcription factors can engage in multiple protein-protein interactions. Accumulating evidence indicates that specific complexes define differentiation lineages and differentiation stages. It is proposed that these complexes acquire new functions during blood cell differentiation through successive changes in composition - much as discussion topics of groups at a cocktail party take new directions as new people join and others leave.

[Indexed for MEDLINE]

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