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Curr Opin Genet Dev. 1998 Oct;8(5):595-602.

Circadian rhythms: molecular basis of the clock.

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Department of Neurobiology and Physiology, Northwestern University, 2153 N. Campus Drive, Evanston, Illinois 60208, USA.


Much progress has been made during the past year in the molecular dissection of the circadian clock. Recently identified circadian genes in mouse, Drosophila, and cyanobacteria demonstrate the universal nature of negative feedback regulation as a circadian mechanism; furthermore, the mouse and Drosophila genes are structurally and functionally conserved. In addition, the discovery of brain-independent clocks promises to revolutionize the study of circadian biology.

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