Combinatorial transcription factors

Curr Opin Genet Dev. 1998 Oct;8(5):552-9. doi: 10.1016/s0959-437x(98)80010-5.

Abstract

Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern assembly of these complexes. Three-dimensional structures have been determined of the MATalpha2/MCM1-DNA complex, the p50/p65 Rel homology domain heterodimer bound to DNA, the NFAT/Fos-Jun/DNA quaternary complex, and of the GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA / chemistry*
  • DNA / genetics
  • DNA / metabolism*
  • Dimerization
  • Humans
  • Macromolecular Substances
  • Models, Molecular
  • Multiprotein Complexes
  • Nucleic Acid Conformation*
  • Protein Conformation*
  • Protein Structure, Secondary
  • Transcription Factors / chemistry*
  • Transcription Factors / metabolism*

Substances

  • Macromolecular Substances
  • Multiprotein Complexes
  • Transcription Factors
  • DNA