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Curr Opin Genet Dev. 1998 Oct;8(5):588-94.

Hypoxia-inducible factor 1: master regulator of O2 homeostasis.

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Institute for Genetic Medicine, CMSC-1004, The Johns Hopkins UniversitySchool of Medicine, 600 N. Wolfe St., Baltimore, Maryland 21287-3914, USA.


Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals. Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.

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