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Curr Opin Genet Dev. 1998 Oct;8(5):576-81.

The nuclear receptor PPARgamma - bigger than fat.

Author information

1
Department of Molecular Endocrinology, Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina, 27709, USA. sak15922@glaxowellcome.com

Abstract

Work reported over the past year has provided insights into the mechanisms whereby ligand activation of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) regulates systemic glucose and lipid homeostasis. PPARgamma has also been implicated recently in the biology of monocytes and in cell-cycle regulation and cancer. Polyunsaturated fatty acids and eicosanoids bind and activate PPARgamma, suggesting that these lipids may serve as hormonal regulators of a variety of biological processes.

PMID:
9794815
DOI:
10.1016/s0959-437x(98)80014-2
[Indexed for MEDLINE]

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