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Science. 1998 Oct 30;282(5390):952-4.

Haldane's rule in taxa lacking a hemizygous X.

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Department of Biology, University of Rochester, Rochester, NY 14627, USA.


Haldane's rule states that species hybrids of the XY sex are preferentially sterile or inviable. In all taxa known to obey this rule, the Y is inert and X-linked genes show full expression in XY individuals. Until recently, all theories of Haldane's rule depended on this hemizygosity. A test of Haldane's rule in animals lacking a hemizygous sex-mosquitoes having two functional sex chromosomes in both sexes-reveals that these species show Haldane's rule for sterility but not inviability. A related group having a "normal" hemizygous X obeys Haldane's rule for both sterility and inviability. These results support the faster male and dominance theories of Haldane's rule.

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